Table 4.
Drugs with anticholinergic effects (adapted from Duran et al., 2013).
| Drug class | Common examples |
|---|---|
| Anticholinergics | Atropine |
| Scopolamine | |
| Hyoscyamine | |
| Belladona alkaloids | |
| Antitussives | Homatropine |
| Antihistamines | Cyproheptadine |
| Promethazine | |
| Diphenhydramine | |
| Dexchorpheniramine | |
| Hydroxyzine | |
| Chlorpheniramine | |
| Brompheniramine | |
| Carbinoxamine | |
| Pyrilamine | |
| Loratadine | |
| Cetirizine | |
| Fexofenadine | |
| Cimetidine | |
| Ranitidine | |
| Antipruritics | Trimeprazine (alimemazine) |
| SSRI/SSNI antidepressants | Venlafaxine* |
| Trazadone | |
| Fluoxetine | |
| Fluvoxamine | |
| Paroxetine | |
| Citalopram | |
| Mirtazapine | |
| Nefazodone | |
| Tricyclic antidepressants | Amitriptyline |
| Doxepin | |
| Imipramine | |
| Nortriptyline | |
| Chlomipramine | |
| Desipramine | |
| Protriptyline | |
| Trimipramine | |
| Dosulepin | |
| MAO inhibitor antidepressants | Phenelzine |
| Anti-anxiety/insomnia | Chlordiazepoxide |
| Clonazepam | |
| Diazepam | |
| Temazepam | |
| Triazolam | |
| Antipsychotics | Chlozapine |
| Chlorpromazine | |
| Fluphenazine | |
| Thioridazine | |
| Thiothixene | |
| Trifluoperazine† | |
| Perphenazine† | |
| Quetiapine | |
| Olanzapine | |
| Risperidone | |
| Ziprasidone | |
| Haloperidol | |
| Loxapine | |
| Molindone | |
| Promazine | |
| Antiparkinsonians | Benztropine |
| Trihexyphenidyl | |
| Procyclidine | |
| Amantadine | |
| Bromocriptine | |
| Entacapone | |
| Anticonvulsants | Carbamazepine |
| Oxcarbazepine | |
| Bladder antispasmodics | Oxybutynin |
| Tolterodine | |
| Darifenacin | |
| Propantheline | |
| Emepronium | |
| Flavoxate | |
| Gastrointestinal relaxants | Dicyclomine |
| Propantheline | |
| Gastric motility stimulant | Metoclopramide† |
| Antiemetics/antivertigo | Levomepromazine |
| Meclozine | |
| Dimenhydrinate | |
| Promethazine | |
| Domperidone | |
| Prochlorperazine | |
| Muscle relaxants | Orphenadrine |
| Tizanidine | |
| Carisoprodol† | |
| Cyclobenzaprine | |
| Methocarbamol | |
| Baclofen | |
| Inhalants/antibronchospastics | Ipratropium |
MOA = monoamine oxidase; SSRI = selective serotonin reuptake inhibitor; SSNI = serotonin–norepinephrine reuptake inhibitor.
Bold font: high-potency anticholinergic activity; normal font: low-potency anticholinergic activity.
*
Little to no anticholinergic effect.
†
Uncertain; high potency in some studies.