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. 2021 Jan 26;4:119. doi: 10.1038/s42003-020-01642-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Schematic plan to evaluate EVs release from LuCaP/PDX models and functional characterization. B miR-424 level in explants of LuCaP #145.2 (mCRPC) and LuCaP#35 (mCSPC) tumor xenografts (n = 2/group). C Level of miR-424 evaluated in EVs derived from indicated PDX. D Tumor-sphere forming assay with RWPE-1 recipient cells incubated with mCRPC and mCSPC xenografts-derived EVs. E Schematic of the experimental plan to block miR-424 in recipient cells. F Level of miR-424 evaluated in recipient cells supplemented with EVs from the indicated PDX sources, following blockade of miR-424 using LNA-CTRL and LNA-424. G SFE in RWPE-1 recipient cells transfected with LNA-CTRL and LNA-424 and subsequent supplementation with EVs from the indicated PDX sources.*p ≤ 0.05, **p ≤ 0.01.