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. 2021 Jan 26;7:24. doi: 10.1038/s41420-020-00379-8

Fig. 6. Activation of mitogen activated protein kinase (MAPK) in ZIKV infected trophoblasts.

Fig. 6

a Immunoblot analysis of JNK and p38 activation via phosphorylation were observed 8–24 h after infection with 0.1 MOI r-MRV in JEG-3 cells showed increase in phosphorylation of p54 and p46 components of JNK and phosphorylation of p38 MAPK as well compared to uninfected vehicle cells. Similarly, JNK and p38 activation via phosphorylation was also observed in JAR cells (b) and HTR-8 (c) 24 h of postinfection with 0.1 MOI r-MRV compared to uninfected vehicle cells. Total JNK and Total p38 levels were mostly unaltered between ZIKV infected and vehicle uninfected cells. d Activation of JNK was also seen with 0.1 MOI PRV 24–48 h of postinfection in JEG-3 cells compared to uninfected vehicle cells.