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. 2021 Jan 26;11:2229. doi: 10.1038/s41598-021-82055-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Antiviral evaluation using SARS-CoV-2 replicon. (A) Antiviral activity of remdesivir. The CHO-K1 cells electroporated with 5 μg of replicon RNA were seeded in a 96-well plate. The cells were treated immediately with 10-μM remdesivir or 0.2% DMSO. Luminescence was measured at 24 h post-treatment. The mean and standard error of two independent experiments are shown in this figure. A one-way ANOVA was performed to determine the statistical significance. A p-value less than 0.05 was considerd to be statistically significant. NS not significant. (B) Calculation of IC₅₀ and CC₅₀. The CHO-K1 cells electroporated with replicon RNA was seeded. The cells were immediately treated with remdesivir at indicated concentrations. Luminescence and cell viability were measured at 24 h post-treatment. IC₅₀ and CC₅₀ values were calculated by GraphPad software. The mean and standard error of two independent experiments are shown in this figure.