Table 2.
Evolution of plasma glucose, NH4+ and bilirubin in BDL, BDL + probiotic, sham and sham + probiotic animals during disease progression.
| BDL | BDL + probiotic | Sham | Sham + probiotic | p value | |
|---|---|---|---|---|---|
| Plasma glucose (mg/dl) | |||||
| Week 0 | 189 ± 6 | 193 ± 6 | 176 ± 19 | 192 ± 3 | ns |
| Week 2 | 148 ± 11 | 154 ± 4 | 158 ± 4 | 171 ± 5 | ns |
| Week 4 | 140 ± 5 | 134 ± 7 | 161 ± 4 | 169 ± 10 | + |
| Week 6 | 111 ± 5 | 97 ± 8 | 156 ± 11 | 187 ± 24 | *,+++ |
| Week 8 | 92 ± 8 | 117 ± 7 | 200 ± 7 | 153 ± 11 | *** |
| Plasma NH4+ (μM) | |||||
| Week 0 | 61.2 ± 3.5 | 68.2 ± 8.5 | 68.9 ± 8.9 | ns | |
| Week 2 | 80.4 ± 5.5 | 93 ± 5.9 | 69.5 ± 11.3 | ns | |
| Week 4 | 106 ± 9.2 | 103.7 ± 10.9 | 50.9 ± 0.6 | * | |
| Week 6 | 126.4 ± 10.1 | 103.0 ± 8.1 | 60.6 ± 3.6 | * | |
| Week 8 | 152.9 ± 26.0 | 124.6 ± 17.1 | 53.9 ± 2.8 | **,+ | |
| Plasma bilirubin (mg/dl) | |||||
| Week 0 | < 0.5 | < 0.5 | < 0.5 | < 0.5 | ns |
| Week 2 | 4.7 ± 0.2 | 5.8 ± 0.5 | < 0.5 | < 0.5 | ns |
| Week 4 | 6.2 ± 0.3 | 6.6 ± 0.3 | < 0.5 | < 0.5 | ns |
| Week 6 | 6.9 ± 0.5 | 7.1 ± 0.4 | < 0.5 | < 0.5 | ns |
Plasma NH4+ showed no difference between shams and shams + probiotic. Therefore, we pooled them together for the analysis. P value: for plasma glucose and plasma NH4+, one-way ANOVA with Bonferroni correction, *significance between BDL and sham groups, +significance between BDL + probiotic and sham groups. ns non-significant. For plasma bilirubin, one-way ANOVA with Bonferroni correction statistics are shown between BDL and BDL + probiotic.