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. 2021 Jan 13;12:627362. doi: 10.3389/fnagi.2020.627362

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Copyright © 2021 Chao, Zhang, Zhang, Jiang, Zhou, Tang, Liang, Fan, Dou and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of FLX on the oligodendrocytes in the hippocampus of APP/PS1 mice. (A) Western blots showing the levels of CNPase, MBP and NG2 in the mouse hippocampus. (B) The relative levels of the CNPase, MBP and NG2 proteins in the hippocampus (x ± SD). (C) Immunofluorescence staining of mature oligodendrocytes (Olig2⁺/CNPase⁺ cells) in the hippocampus. Arrows (→) indicate Olig2⁺/CNPase⁺ cells. Bar = 50 μm. (D) The ratio of mature oligodendrocytes to oligodendrocyte lineage cells in the hippocampus (x ± SD). (E) Immunofluorescence staining of immature newborn mature oligodendrocytes (BrdU⁺/Olig2⁺/CNPase⁺ cells) in the hippocampus. Arrows (→) indicate BrdU⁺/Olig2⁺/CNPase⁺ cells. Bar = 50 μm. (F) The ratio of newborn mature oligodendrocytes to newborn oligodendrocyte lineage cells in the hippocampus (x ± SD). *p < 0.05. **p < 0.01.