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. 2021 Jan 13;12:627362. doi: 10.3389/fnagi.2020.627362

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Copyright © 2021 Chao, Zhang, Zhang, Jiang, Zhou, Tang, Liang, Fan, Dou and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of FLX on GSK3β and 5-HT1AR levels in the hippocampus of APP/PS1 mice. (A) Western blots showing the levels of GSK3β, p-S9-GSK3β and 5-HT1AR in the hippocampus. (B) The relative levels of the GSK3β, p-S9-GSK3β and 5-HT1AR proteins in the hippocampus (x ± SD). *p < 0.05. **p < 0.01. (C) Immunofluorescence staining for 5-HT1AR in oligodendrocyte precursor cells (5-HT1AR⁺/PFDGαR⁺ cells, indicated with arrows) and mature oligodendrocytes (5-HT1AR⁺/CNPase⁺ cells, indicated with arrows) in the hippocampus. Bar = 50 μm. (D) The densities (x ± SD) of oligodendrocyte precursor cells expressing 5-HT1AR (5-HT1AR⁺/PFDGαR⁺ cells) in the hippocampus. (E) The densities (x ± SD) of mature oligodendrocytes expressing 5-HT1AR (5-HT1AR⁺/CNPase⁺ cells) in the hippocampus.