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. 2021 Jan 13;14:598198. doi: 10.3389/fncel.2020.598198

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Copyright © 2021 Tang, Qin, Li, Chen, Ulloa, Zhu, Liu, Gong, Zhao, Wang, Li, Guo, Xu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P2RX3, P2RX7, and TRPV1 mediates acupuncture-induced awakening effect in TBI rodents. (A,B) Experimental representation of the lateral intracerebroventricular (i.c.v) and vPAG intranuclear injection of blockers 0.5 h before starting TBI. (C–E) Time duration of the TBI-induced coma in control rats, treated with HTWP acupuncture (hand Acu), or pretreated with intraventricular injection of specific antagonists against (C) P2RX7, (D) P2RX3, or (E) TRPV1 (n = 6/group; one-way ANOVA). (F) Time duration of the TBI-induced coma in control rats, treated with HTWP acupuncture (hand Acu), or pretreated with vPAG intranuclear injection of a specific antagonist against P2RX7 (n = 6/group; one-way ANOVA). Error bars represent mean + SEM; *P < 0.05, **P < 0.01 vs. Sham; ^▴P < 0.05, ^▴▴P < 0.01 vs. TBI. (G) Scientific hypothesis proposing that HTWP acupuncture activates vPAG dopaminergic neurons to express P2PX7 to enhance dopaminergic connections with the hypothalamic tuberomammillary nucleus histamine neurons (expressing DRD3).