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. 2021 Jan 26;11:2271. doi: 10.1038/s41598-021-81927-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association with baseline CRP levels and depression symptoms at follow-up in men and women. We observed gender differences regarding the association of elevated levels of CRP at baseline with new onset of depression at follow-up: in men, elevated CRP at baseline was associated with higher PHQ-9 scores at follow-up; whereas in women, no clear effect of baseline CRP on PHQ-9 at follow-up was apparent. The plot results show the probability (p) and 95% confidence intervals of depression (PHQ-9 ≥ 10) estimated based on the regression model of the total sample (reported in Table 2), depending on baseline CRP (normal versus elevated) and other predictors held fixed. (Figures were created using R version 3.6.1 https://www.R-project.org/).