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. 2021 Jan 26;11:2271. doi: 10.1038/s41598-021-81927-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction plot between gender and natural log of white blood cell count as predictors of new onset of depression 5 years later. There were differences between men and women with respect to the association of elevated levels of WBC at baseline with new onset of depression at follow-up: in men, elevated WBC at baseline was more closely associated with higher PHQ-9 sum scores at follow-up. The plot results show the probability (p) and 95%-confidence intervals (shaded areas) of depression (PHQ-9), estimated based on the regression model of the total sample (reported in Table 4), depending on baseline natural log of WBC and other predictors held fixed. (Figures were created using R version 3.6.1 https://www.R-project.org/).