Table 3.
Results of the logistic regression analysis: Prediction of new onset of depression at follow-up (based on predictors measured at baseline 5 years earlier, including CRP ≥ 3 mg/l), stratified by gender.
| Predictors | Men Nagelkerke R2 = 0.38 |
Women Nagelkerke R2 = 0.37 |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Inflammation | ||||||
| CRP ≥ 3 mg/l | 1.49 | 1.03; 2.16 | 0.033 | 0.92 | 0.63; 1.36 | 0.68 |
| Sociodemographic | ||||||
| Age | 0.99 | 0.97; 1.00 | 0.023 | 0.97 | 0.95; 0.99 | < 0.001 |
| Living with partner | 1.29 | 0.80; 2.10 | 0.30 | 1.06 | 0.71; 1.58 | 0.79 |
| Socioeconomic status | 0.99 | 0.95; 1.03 | 0.60 | 1.00 | 0.95; 1.04 | 0.87 |
| Physical health and health behavior | ||||||
| Diabetes | 1.54 | 0.89; 2.67 | .12 | 0.87 | 0.34; 2.23 | 0.76 |
| CVD | 1.01 | 0.58; 1.78 | 0.97 | 1.21 | 0.61; 2.42 | 0.59 |
| Cancer | 0.85 | 0.41; 1.75 | 0.65 | 1.82 | 1.11; 2.99 | 0.018 |
| Obesity | 0.98 | 0.67; 1.44 | 0.92 | 0.76 | 0.48; 1.18 | 0.22 |
| Smoker | 1.53 | 1.05; 2.22 | 0.027 | 1.31 | 0.89; 1.92 | 0.17 |
| Physical activity | 1.00 | 1.00; 1.00 | 0.54 | 1.00 | 1.00; 1.00 | 0.85 |
| Alcohol > recom. limit | 0.97 | 0.68; 1.40 | 0.88 | 0.67 | 0.44; 1.00 | 0.049 |
| Mental distress | ||||||
| Loneliness | 1.92 | 1.18; 3.10 | 0.008 | 1.75 | 1.14; 2.69 | 0.011 |
| PHQ-9 sum (baseline) | 1.56 | 1.46; 1.67 | < 0.001 | 1.38 | 1.30; 1.48 | < 0.001 |
Bold values indicate statistically significant predictors.
CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, OR odds ratio, PHQ-9 patient health questionnaire-9.