Table 4.
Results of the logistic regression analysis: Prediction of new onset of depression at follow-up (based on predictors measured at baseline 5 years earlier, including the natural logarithm of WBC).
| Predictors | OR | 95% CI | p |
|---|---|---|---|
| Inflammation | |||
| Ln(WBC) | 1.88 | 1.04; 3.42 | 0.04 |
| Interaction: Ln(WBC)* Gender (women) | 0.37 | 0.16; 0.87 | 0.023 |
| Sociodemographic | |||
| Gender (women) | 7.91 | 1.48; 42.33 | 0.02 |
| Age | 0.98 | 0.97; 0.99 | < 0.001 |
| Living with partner | 1.13 | 0.83; 1.54 | 0.43 |
| Socioeconomic status | 0.99 | 0.97; 1.02 | 0.65 |
| Physical health and health behavior | |||
| Diabetes | 1.38 | 0.87; 2.19 | 0.17 |
| CVD | 1.14 | 0.74; 1.76 | 0.55 |
| Cancer | 1.39 | 0.93; 2.09 | 0.11 |
| Obesity | 0.89 | 0.67; 1.18 | 0.41 |
| Smoker | 1.37 | 1.04; 1.80 | 0.02 |
| Physical activity | 1.00 | 1.00; 1.00 | 0.81 |
| Alcohol > recom. limit | 0.86 | 0.66; 1.12 | 0.25 |
| Mental distress | |||
| Loneliness | 1.82 | 1.32; 2.50 | < 0.001 |
| PHQ-9 sum (baseline) | 1.47 | 1.4; 1.54 | < 0.001 |
Bold values indicate statistically significant predictors.
Total model: Nagelkerke R2 = 0.37.
CI confidence interval, CVD cardiovascular disease, OR odds ratio, PHQ-9 patient health questionnaire-9, WBC white blood cell count.