Table 5.
Results of the logistic regression analysis: prediction of new onset of depression at follow-up (based on predictors measured at baseline 5 years earlier, including the natural logarithm of WBC), stratified by gender.
| Predictors | Men Nagelkerke R2 = 0.25 |
Women Nagelkerke R2 = 0.29 |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | |
| Inflammation | ||||||
| Ln(WBC) | 1.80 | 0.96; 3.37 | 0.07 | 0.72 | 0.38; 1.36 | 0.31 |
| Sociodemographic | ||||||
| Age | 0.99 | 0.97; 1.01 | 0.025 | 0.97 | 0.95; 0.99 | < 0.001 |
| Living with partner | 1.27 | 0.79; 2.07 | 0.33 | 1.05 | 0.70; 1.56 | 0.82 |
| Socioeconomic status | 0.99 | 0.95; 1.03 | 0.66 | 1.00 | 0.95; 1.04 | 0.83 |
| Physical health and health behavior | ||||||
| Diabetes | 1.58 | 0.91; 2.72 | 0.10 | 0.89 | 0.34; 2.29 | 0.80 |
| CVD | 1.00 | 0.57; 1.76 | 0.99 | 1.33 | 0.68; 2.62 | 0.41 |
| Cancer | 0.88 | 0.43; 1.82 | 0.73 | 1.79 | 1.09; 2.95 | 0.021 |
| Obesity | 1.02 | 0.70; 1.49 | 0.90 | 0.75 | 0.49; 1.15 | 0.19 |
| Smoker | 1.42 | 0.96; 2.10 | 0.08 | 1.36 | 0.92; 2.01 | 0.12 |
| Physical activity | 1.00 | 1.00; 1.00 | 0.51 | 1.00 | 1.00; 1.00 | 0.83 |
| Alcohol > recom. limit | 1.02 | 0.71; 1.46 | 0.93 | 0.66 | 0.44; 1.00 | 0.047 |
| Mental distress | ||||||
| Loneliness | 1.89 | 1.17; 3.05 | 0.01 | 1.75 | 1.14; 2.69 | 0.011 |
| PHQ-9 sum (baseline) | 1.56 | 1.45; 1.67 | < 0.001 | 1.38 | 1.30; 1.48 | < 0.001 |
Bold values indicate statistically significant predictors.
CVD cardiovascular disease, PHQ-9 patient health questionnaire-9, WBC white blood cell count.