Table 3.

The different MBI-C domains as predictors of tau deposition in Braak region I-II.

Model	β	SE	p	2ΔR2	1R2
Braak I-II ~ MBI-C Drive	0.030	0.017	0.088	0.055	0.195
Braak I-II ~ MBI-C Affective	0.025	0.009	0.006	0.138	0.277
Braak I-II ~ MBI-C Control	0.020	0.006	0.003	0.158	0.298
Braak I-II ~ MBI-C Social	0.028	0.031	0.134	0.015	0.155
Braak I-II ~ MBI-C Perception	0.011	0.052	0.835	0.001	0.140
P-tau181 ~ MBI-C Drive	4.181	2.400	0.088	0.058	0.156
P-tau181 ~ MBI-C Affective	3.302	0.268	0.008	0.136	0.233
P-tau181 ~ MBI-C Control	2.347	0.907	0.013	0.119	0.216
P-tau181 ~ MBI-C Social	2.897	4.340	0.508	0.009	0.106
P-tau181 ~ MBI-C Perception	2.880	7.146	0.689	0.003	0.101

Multivariate linear regression analyses in 50 CU Aβ-positive subjects, to investigate the association between tau deposition in Braak stage I-II or using CSF P-tau₁₈₁, and the five different MBI-C domains (Drive and motivation [Drive], Affective regulation [Affective], Impulse dyscontrol [Control], Social inappropriateness [Social], Perception and thought [Perception]). Models were adjusted for age, sex, education, and WML volume. [¹⁸F]RO948-PET SUVR in Braak stage I-II or CSF P-tau₁₈₁ was entered as a continuous dependent variable. Continuous MBI-C domain scores, respectively, were entered as the independent variable. ¹R² for the complete model. ²Change in R² when adding MBI to models initially only including the covariates.

β beta coefficient, Aβ amyloid-β, CU cognitively unimpaired, MBI-C mild behavioral impairment – checklist, p p-value, P-tau₁₈₁ phosphorylated tau 181, R² the coefficient of determination, SE standard error, SUVR standard uptake value ratio.