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Selected Agents Used in Elderly AML Patients
| Agent | Mechanism of Action |
|---|---|
| 5-azacytidine (azacitidine), 5-aza-2′-deoxycytidine (decitabine) | Inhibitors of DNA methylation |
| Gemtuzumab ozogamicin | Recombinant anti-CD33 humanized antibody linked to N-acetyl-γ- calicheamicin |
| Clofarabine | Second-generation purine nucleoside analog |
| Tipifarnib | Farnesyltransferase inhibitor |
| Lestaurtinib | FMS-like tyrosine kinase 3 (FLT-3) inhibitor |
| Sapacitabine | Cytosine nucleoside analog |
