Fig. 3.

Resveratrol is involved in anti-aging as an activator of the sirtuin family and the Nrf2 pathway. Inhibition of mitochondrial ATP production by resveratrol leads to activation of AMPK, which enhances NAD + availability thereby overcoming the rate limitation imposed by this cofactor on SIRT1 enzyme activity. In turn, resveratrol directly activates SIRT1 thereby positively controlling AMPK activity. Together, AMPK and SIRT1 form a positive feedback pathway to prolong life by modulating multiple downstream factors. In addition, resveratrol can act directly on transcriptional regulators thus acting as an anti-inflammatory and antioxidant effect