Fig. 4.

Senolytic therapies target aging. During the aging process, senescent cells accumulate in large amounts in tissues and are associated with the development of various age-related diseases. Senolytics can help slow down the aging process by eliminating the accumulation of senescent cells, reducing age-related diseases and prolonging healthspan. Uncontrolled activation of SASP can cause chronic inflammation, leading to tissue dysfunction, this ultimately leads to aging and age-related diseases. Senolytics also can positively impact aging-related diseases by modulating the regulatory network of SASP in senescent cells and by inhibiting SASP from exerting its deleterious effects