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. 2021 Jan 13;14:604583. doi: 10.3389/fnins.2020.604583

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Copyright © 2021 Castillo-Rolón, Ramírez-Sánchez, Arenas-López, Garduño, Hernández-González, Mihailescu and Hernández-López.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The activation of α7 nAChRs with a selective agonist mimicked the effect of nicotine. (A) Current traces showing sEPSCs in control condition (left), 10 min after the application of PNU-282987, a selective agonist of α7 nAChRs (PNU 100 nM, middle), and 20 min after PNU washout (right). (B) Time-frequency histogram showing the time course of PNU effects (n = 6). (C), Current traces showing sEPSCs in control condition (left), 10 min after the application of RJR-2403, a selective agonist of the α4β2 nAChRs (RJR 100 nM, middle), and 20 min after RJR washout (right). (D) Normalized time-frequency histogram showing the lack of effect of RJR (n = 6). (E) Summary of the data (Mann–Whitney U-test). **p < 0.01.