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. 2021 Jan 13;14:604583. doi: 10.3389/fnins.2020.604583

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Copyright © 2021 Castillo-Rolón, Ramírez-Sánchez, Arenas-López, Garduño, Hernández-González, Mihailescu and Hernández-López.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blockage of intracellular calcium stores abolishes the effects of nicotine. (A) Time-frequency histogram showing the lack of effect of nicotine on the sEPSC frequency in the presence of the SERCA blocker thapsigargin (10 μM) (n = 6). (B) Time-frequency histogram showing the lack of effect of nicotine on the sEPSC frequency in the presence of cyclopiazonic acid (CPA, 10 μM) (n = 6). (C) Time-frequency histogram showing that nicotine had strong effects on sEPSCs in the presence of cadmium (100 μM), a blocker of the VGCCs (n = 6). (D) Bar graph illustrating a summary of the data (Mann–Whitney U-test). ***p < 0.001.