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. 2021 Jan 13;11:601628. doi: 10.3389/fneur.2020.601628

Figure 1.

Figure 1

OCT scan of C57Bl/6J mouse retina and ON-crush with GSH in optic nerve and retinal scans. (A) Retinal fundus and B-scans of mice before and 7 weeks after ON-crush with Heidelberg Engineering Spectralis™ HRA+OCT device with semi-automated segmentation of the retinal layers. ILM, Inner Limiting Membrane; RNFL, Retinal Nerve Fiber Layer; IPL, Inner Plexiform Layer; INL, Inner Nuclear Layer; OPL, Outer Plexiform Layer; ELM, External Limiting Membrane; BM, Bruch's Membrane; RPE, Retinal Pigment Epithelium. (B) The GSH concentration in optic nerve tissue of mice treated with 15 or 30 mg/kg BW DMF at 7 weeks after ONC. Degeneration of the (C) total retinal thickness and (D) inner retinal layers and of mice over 7 weeks after ONC. All graphs represent the pooled mean ± SEM; n = 3 animals per group. ***p < 0.001 by ANOVA with Dunnett's post hoc test compared to vehicle for (A) and area under the curve compared by ANOVA with Dunnett's post hoc test for time courses compared to control for (C) and (D).