Figure 5.

Dose-dependent prophylactic effect of phenytoin and, leaf and stem bark A. senegalensis extracts. (A) Normalized % of recovery at t = 0 for females and males. The concentration is in log₁₀ scale. An ANOVA comparing the effect of the three drugs treatment was significant [F_(2,199) = 15.06, p < 0.0001, η² = 0.13]. A post hoc Bonferroni multiple comparisons test was used to test for differences between the drugs (phenytoin vs. leaf p < 0.0001; vs. stem p = 0.35 and leaf vs. stem p = 0.0001). No significant differences between concentrations of each drug were found, apart when comparing with the control (Tukey's multiple comparisons test). (B) Amount of food ingested per fly and per 24 h. A two way ANOVA showed no effect of drug [F_(1,103) = 0.03, p = 0.86], no effect of concentration [F_(5,103) = 1.63, p = 0.16] and no interaction [F_(5,103) = 1.26, p = 0.28]. A post hoc Dunnett's multiple comparisons test comparing the control with each treatment did not yield any significant differences.