Table 2.

Effect of Annona senegalensis treatments on the seizure-like phenotype of eas^2F flies.

Treatment eas2F flies	Concentration (mg.ml-1)	% of recovery at t = 0
		Females			Males
		(Mean ± SEM)	p	n (# flies)	(Mean ± SEM)	p	n (# flies)
Control	0	6.73 ± 3.09		13 (115)	0.63 ± 0.63		16 (137)
A. senegalensis	2.67	0	ns	8 (73)	1.25 ± 1.25	ns	8 (69)
Leaf extract	26.6	0	ns	6 (54)	0	ns	8 (75)
A. senegalensis	2.67	0	ns	8 (73)	1.39 ± 1.39	ns	8 (73)
Stem Bark extract	26.6	1.39 ± 1.39	ns	10 (92)	4.26 ± 2.11	ns	8 (74)
		Mean recovery time
Control	0	50.86 ± 2.73		105	79.17 ± 3.27		133
A. senegalensis	2.66	59.59 ± 3.58	ns	73	83.33 ± 4.83	ns	72
Leaf extract	26.6	70.00 ± 3.72	<0.001	54	81.20 ± 4.85	ns	92
A. senegalensis	2.66	58.29 ± 3.39	ns	70	77.67 ± 4.68	ns	73
Stem Bark extract	26.6	66.49 ± 3.71	0.001	74	70.87 ± 4.55	ns	69

Percentage of recovery at t =0. Kruskal-Wallis tests comparing each treatment were non-significant for females [${\chi }_{(5)}^2$ = 6.45, p = 0.17] and males [${\chi }_{(5)}^2$ = 7.66, p = 0.1]. The result of Dunn's post hoc test comparing each treatment against the control for each sex is included in the p column of the table. The n (# flies) column shows the number of replicates (n) and flies tested for each treatment.

Mean recovery time. Kruskal-Wallis test comparing each treatment showed a significant effect for females [${\chi }_{(5)}^2$ = 23.98, p < 0.0001] but not for males [${\chi }_{(5)}^2$ = 4.34, p = 0.36]. The result of Dunn's post hoc test comparing each treatment against the control for each sex is included in the p column of the table. The number of flies seizuring at t = 0 is shown in column n.