Fig. 2. Age-dependent changes in myocardial substrate oxidation and ventricular function in control (db/+, red columns) and type 2 diabetic (db/db, yellow columns) mice. (A) Reduction of glucose oxidation in db/db hearts after 10–12 weeks, while fatty acid oxidation had already significantly increased at 6 weeks (B), preceding the decline of left ventricular function (C), measured as PSP times CO. Modified from Aasum et al.⁵¹.

PSP, peak systolic pressure; CO, cardiac output.

^*p<0.05 vs. db/+; ^†p<0.05 vs. 6 week.