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. 2021 Jan 22;62(1):24. doi: 10.1167/iovs.62.1.24

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Copyright 2021 The Authors

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Figure 2. — miR-665-3p negatively regulated ATG5. (A) The potential targets of miR-665-3p were predicted by integrating the results of different algorithms. (B) The 3'UTR of ATG5 contains the complementary site for the seed region of miR-665-3p. (C) A luciferase reporter assay was used to determine whether miR-665-3p directly targeted the ATG5 3′UTR in HEK293T cells. (D, E) Treatment with a miR-665-3p antagomir increased the expression of ATG5 protein compared with miR-NC, whereas opposite trends were observed after treatment with a miR-665-3p agomir in mouse corneal stromal cells. n = 6; **P < 0.01, ***P < 0.001.