Figure 2.

Schematic representation of the functions of RCC2 in the cell cycle process. In prophase, RCC2 is located at the chromosome primary constriction. In prometaphase, RCC2 binds to microtubules and converts GTP-Rac1 to GDP-Rac1, which plays a vital role in association of kinetochores with spindle microtubules and association of passenger proteins with inner centromeres. Moreover, RCC2 acts as a GEF for RalA, which converts GDP-RalA to GTP-RalA thus modulating kinetochore-microtubule interactions by regulating CPC. In metaphase, RCC2 migrates to the equator together with CPC. In anaphase, RCC2 is incorporated into the telophase disc organelle, thus fully partitioning the cell at the spindle equator in late anaphase and telophase.