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. 2021 Jan 13;7:620973. doi: 10.3389/fmolb.2020.620973

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Copyright © 2021 Guo, Zhao, Lang, Wang, Zheng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the role of RCC2 in therapeutic resistance of cancer treatment through regulation of related proteins. (A) The left side shows the common chemotherapy drugs, bortezomib, STS, and DDP, and radiotherapy, which are used for cancer treatment by inducing tumor cell apoptosis. (B) The right side shows how RCC2 regulates some special proteins, (Xpo1, Rac1, RalA), and signaling pathways (JAK-STAT, DNMT1/p-STAT3), which result in attenuated anti-cancer effect of therapeutics, leading to therapeutic resistance.