Table 2.
Localization and expression of proteins interacting with both kappa and lambda light chain.
| Cell surface protein | Intracellular protein | Renal expression score | Nephron tubule expression score | Interacting light chain |
|---|---|---|---|---|
| C1QTNF2 | 64.79 | n.a. | λ and κ | |
| CCNG1 | 99.18 | 99.48 | λ and κ | |
| CYAT1 | n.a. | n.a. | λ and κ | |
| DIXDC1 | 85.59 | 81.60 | λ and κ | |
| FAM160B2 | 97.55 | 62.70 | λ and κ | |
| GDPD5 | 79.12 | n.a. | λ and κ | |
| KCNAB1 | 72.78 | 53.25 | λ and κ | |
| LPAR4 | 84.89 | n.a. | λ and κ | |
| PARS2 | 78.19 | n.a. | λ and κ | |
| PCSK7 | 89.41 | 74.10 | λ and κ | |
| PPP2R5D | 91.03 | 78.49 | λ and κ | |
| QDPR | 98.49 | 89.84 | λ and κ | |
| RNF7 | 97.33 | 91.09 | λ and κ | |
| SCLT1 | 92.75 | n.a. | λ and κ | |
| SIRPB1 | 71.03 | n.a. | λ and κ | |
| SNX33 | 84.09 | n.a. | λ and κ | |
| TMEM106B | 98.45 | 90.42 | λ and κ | |
| TMEM116 | 90.93 | n.a. | λ and κ | |
| TRGC1 | 68.89 | n.a. | λ and κ | |
| VRK2 | 86.66 | 73.99 | λ and κ | |
| ZADH2 | 89.07 | n.a. | λ and κ |
Kappa and lambda LC interaction proteins were categorized for membrane domain containing cell surface or intracellular/cytoplasmic localization (according to the Human Protein Atlas and UniProt database). Renal expression was ascertained and the expression score for adult kidney as well as nephron tubule was extracted from the Bgee database (n.a. = data not available). Detailed protein names are listed in Supplementary Table 1.