Table 3.
Localization and expression of interacting proteins unique to either lambda or kappa light chain.
| Cell surface protein | Intracellular protein | Renal expression score | Nephron tubule expression score | Interacting light chain |
|---|---|---|---|---|
| AQP5 | 70.48 | n.a. | λ | |
| CLIP4 | 85.19 | n.a. | λ | |
| COX15 | 92.96 | 89.43 | λ | |
| FAM127B | 96.03 | 73.64 | λ | |
| GARS | 96.88 | 93.36 | λ | |
| IL12RB1 | 66.12 | n.a. | λ | |
| KCNAB2 | 94.79 | 83.70 | λ | |
| MECR | 92.97 | 75.24 | λ | |
| PRH1 | 72.97 | n.a. | λ | |
| RBM47 | 99.70 | 98.71 | λ | |
| RPRD1A | 92.19 | 80.74 | λ | |
| TLK1 | 95.59 | 91.95 | λ | |
| TRIM21 | 83.33 | n.a. | λ | |
| VDR | 90.64 | 93.84 | λ | |
| WIPF1 | 89.61 | 83.53 | λ | |
| ZDHHC5 | 94.03 | n.a. | λ | |
| ALB | 98.91 | 99.79 | λ | |
| CRYZ | 99.26 | 99.22 | λ | |
| ECHDC1 | 97.28 | 91.70 | λ | |
| BAIAP2L1 | 84.89 | n.a. | κ | |
| CDK10 | 98.99 | 85.38 | κ |
The upper part of the table demonstrates lambda specific, the lower part kappa specific binding partners.
Kappa and lambda LC interaction proteins were categorized for membrane domain containing cell surface or intracellular/cytoplasmic localization (according to the Human Protein Atlas and UniProt database). Renal expression was ascertained and the expression score for adult kidney as well as nephron tubule was extracted from the Bgee database (n.a. = data not available). Detailed protein names are listed in Supplementary Table 1.