Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 13;8:595096. doi: 10.3389/fbioe.2020.595096

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Fu, Chen, Li, Yang, Yang, Quan, Huang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic of the experimental design. Dental pulp extracellular matrix (DPEM) obtained from dental pulp tissues was fabricated into laminin-modified DPEM in this study. Treated dentine matrix (TDM) harvested from extracted teeth were used to simulate the dental pulp cavity. Then, laminin-modified DPEM as well as DPEM combined with TDM were transplanted into fresh premolar alveolar sockets for dental pulp regeneration. Meanwhile, dental pulp stem cells (DPSCs) were also isolated and cultured for in vitro experiments. A, TDM fabrication; B, cell culture; C, decellularization; D, laminin coating; E, DPSCs co-cultured with laminins in vitro; F, orthotopic transplantation; DPSCs, dental pulp stem cells; TDM, treated dentine matrix; DPEM, dental pulp extracellular matrix.