Figure 2.

Overexpression of miR-146a inhibited proliferation and enhanced apoptosis and chemosensitivity. CAOV3 cells were transfected with miR-146a mimics. (A) Relative mRNA expression of miR-146a is shown. (B) Cell proliferation was determined, and the growth curve is shown. (C) Apoptosis was determined, and percentage of apoptotic cells is shown. (D) OVCAR3 cells were transfected with miR-146a mimics and then treated by 400 ng/ml paclitaxel for 48 h. After that, cell viability was assessed by MTT. #p < 0.05 indicates statistical significance, compared with scramble. ##p < 0.05 indicates statistical significance, compared with paclitaxel and miR-146a.