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. 2016 May 2;23(6):275–282. doi: 10.3727/096504016X14562725373798

Figure 5.

Figure 5

Role of reduction of SOD2 in miR-146a-mediated inhibition of EOC. CAOV3 cells were transfected with miR-146a mimics with or without plasmids expressing SOD2. (A) Cell proliferation was determined, and the growth curve is shown. (B) Apoptosis was determined, and percentage of apoptotic cells is shown. (C) OVCAR3 cells were transfected with miR-146a mimics with or without plasmids expressing SOD2 and then treated by 400 ng/ml paclitaxel for 48 h. After that, cell viability was assessed by MTT. (D) Role of reduction of SOD2 in miR-146a-mediated inhibition of EOC. #p < 0.05 indicated statistical significance, compared with scramble. ##p < 0.05 indicated statistical significance, compared with paclitaxel + miR-146a.