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. 2016 May 11;24(1):65–72. doi: 10.3727/096504016X14587366983838

Figure 4.

Figure 4

ROS plays a critical role in cell death in renal cancers induced by ABT-737 and chloroquine. (A) The effect of ABT-737 and chloroquine on ROS induction in A498 cells, and ABT-737 could induce the production of ROS. (B) The effect of NAC and trolox on ROS of A498 cells induced by 1 µmol/L of ABT-737 and 25 µmol/L of chloroquine alone or combination of these two reagents in 72 h. NAC and trolox were used to scavenge ROS produced by ABT-737. (C) The effect of ROS inhibitors on apoptosis of A498 cells induced by a combination of 1 µmol/L of ABT-737 and 25 µmol/L of chloroquine. NAC and trolox inhibited the cell apoptosis. *p < 0.05.