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Working model for synergistic cell death induced by ABT-737 and chloroquine. On one hand, ABT-737 could induce cell apoptosis by inhibiting prosurvival Bcl-2 proteins and activating caspases directly; on the other hand, ABT-737 could increase the cell level of ROS produced by mitochondrial, which triggers cathepsin-mediated cell death and augments the role of chloroquine on cell death.
