TABLE 2.

Heterogeneity and pleiotropy analysis of T2D, FG and 2hGlu with hip and knee OA risk using different analytic methods.

Exposure traits	MR methods	Hip OA					Knee OA
		Cochran Q statistic	I2	Heterogeneity p-value	MR-Egger		Cochran Q statistic	I2	Heterogeneity p-value	MR-Egger
					Intercept	Intercept p-value				Intercept	Intercept p-value
T2D	MR-Egger	30.1362	<0.0001	0.6104	−0.0105	0.1367	33.5130	0.0153	0.4424	0.0033	0.5589
	Inverse variance weighted	32.4634	<0.0001	0.5430			33.8671	<0.0001	0.4741
	Maximum likelihood	32.4633	<0.0001	0.5430			33.8592	<0.0001	0.4745
FG	MR-Egger	11.6746	0.2291	0.1663	0.0243	0.1189	13.8053	0.4205	0.0870	−0.0078	0.5348
	Inverse variance weighted	16.1241	0.4418	0.0643			14.5310	0.3806	0.1047
	Maximum likelihood	16.1240	0.4418	0.0643			14.5175	0.3801	0.1051
2hGlu	MR-Egger	2.2054	0.5466	0.1375	0.0303	0.6639	0.0204	<0.0001	0.8863	−0.0222	0.5722
	Inverse variance weighted	2.9551	0.3232	0.2282			0.6533	<0.0001	0.7213
	Maximum likelihood	2.8701	0.3032	0.2381			0.6503	<0.0001	0.7224

MR, Mendelian randomization; OA, osteoarthritis; T2D, type 2 diabetes; FG, fasting glucose; 2hGlu, 2-hour postprandial glucose.