TABLE 3.

Power calculation for the MR analysis in current study.

Exposure		Outcome			OR	Proportion of variance explained by the SNPs on exposure	Power
Trait	Sample size	Trait	Sample size	Proportion of cases
T2D	659,316	Hip OA	382,833	0.0336	1.1708	0.0508	99%
T2D	659,316	Knee OA	391,904	0.0559	0.9046	0.0508	87%
FG	133,010	Hip OA	382,833	0.0336	0.4634	0.0029	91%
FG	133,010	Knee OA	391,904	0.0559	0.5890	0.0029	91%
2hGlu	42,854	Hip OA	382,833	0.0336	1.3062	0.0074	83%
2hGlu	42,854	Knee OA	391,904	0.0559	1.3652	0.0074	99%

T2D, type 2 diabetes; FG, fasting glucose; 2hGlu, 2-h postprandial glucose; OA, osteoarthritis; OR, odds ratio; SNP, single nucleotide polymorphism.