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. 2016 Oct 27;24(6):463–475. doi: 10.3727/096504016X14685034103671

Figure 8.

Figure 8

siRNA-PKM2 regulated the tumor suppressor genes and oncogenes. (A and C) The mRNA expression levels of the tumor-related genes caspase 7, Bad, and E-cadherin were upregulated, whereas MMP2, HIF1α, VEGF, and MMP9 were depressed in the siRNA-PKM2 group compared with the controls. (B and D) The protein levels of the tumor-related genes caspase 7, Bad, and E-cadherin were upregulated, whereas MMP2, HIF1α, VEGF, and MMP9 were downregulated. n = 3, mean ± SD. ***p < 0.001 versus Control, ###p < 0.001 versus Negative Control.