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Knockdown of SPOCK1 inhibits CRC cell migration and invasion by reversing the EMT process. HCT116 cells were transfected with shSPOCK1 or shNC for 48 h. (A) The migration of HCT116 cells was evaluated by a Transwell assay. (B) The invasiveness of HCT116 cells was evaluated by a Matrigel-coated Transwell assay. (C) The expression levels of EMT markers were measured using Western blot analysis. Data are expressed as mean ± SD. *p < 0.05 compared with the shNC group.
