TABLE 1.
Ionic currents responsible for the action potential in ventricular myocytes from adult human, zebrafish embryo, adult zebrafish, adult rat, and human-induced pluripotent stem cell-derived cardiac myocytes (hIPSC-CMs).
| Adult Human |
Zebrafish Embryo |
Adult Zebrafish |
Adult Rat |
hIPSC-CMs |
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| Channel | Accesory subunit | Channel | Accesory subunit | Channel | Accesory subunit | Channel | Accesory subunit | Channel | Accesory subunit | |
| INa | Nav1.5 | Navβ | Nav1.5 | ?? | Nav1.5 | Navβ | Nav1.5 | Navβ | Nav1.5 | ?? |
| ICa–L | Cav1.2 | β; α2δ | Cav1.2 | β; α2δ | Cav1.2 | β; α2δ | Cav1.2 | β; α2δ | Cav1.2 | ?? |
| ICa–T | – | – | Cav3.2 | – | Cav3.2 | – | – | – | Cav3.2 | – |
| Ito | Kv4.3 | MIRP1 | – | – | – | – | Kv4.3; Kv4.2 | MIRP1 | Kv4.3 | – |
| IKr | hERG1 | hERG? | hERG2 | – | hERG1 | |||||
| IKs | Kv71. | MinK | – | – | Kv7.1 | – | – | – | Kv7.1 | – |
| IK1 | Kir2.1; 2.2; 2.3 | – | Kir2.4 | – | Kir2.4 | – | Kir2.1; 2.2; 2.3 | – | Kir2.1; ??;?? | – |
| IK | – | – | – | – | – | – | Kv2.1 | – | – | – |
Correlation with the different pore-forming α-subunits (Channel) and accessory proteins. Different font sizes represent different expression levels.