Fig. 4.

HMLF diet increased the abundance of porphyromonadaceae family of bacteria. (A) Between-group T-test analysis and (B) MetaStat of fecal samples of normal chow and HMLF diet groups. *P < 0.05 or *Q < 0.05 vs normal chow group. n = 5 per group. (C) Cladogram diagram showing the microbial species with significant differences. Circles radiating from inside to outside represent the taxonomic rank: phylum, class, order, family, and genus. Red nodes in the phylogenetic tree denote microbial species that play crucial role in the HMLF diet group. Yellow nodes stand for those microbial species with no significant difference. HMLF: high methionine low folate. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)