Table 5.
DOG1 Expression Status and Correlation With Mutational Status of KIT and PDFGRA Genes
| Target Gene/Exon | % (n) | DOG1 Negative [% (n)] | DOG1 Positive [% (n)] | p |
|---|---|---|---|---|
| Total | 100 (46) | 34.8 (16) | 65.2 (30) | |
| KIT gene | ||||
| Overall | ||||
| Wild type | 37 (17) | 52.9 (9) | 47.1 (8) | 0.04 |
| Mutant | 63 (29) | 24.1 (7) | 75.9 (22) | |
| Exon 9 | ||||
| Wild type | 89.1 (41) | 39 (16) | 61 (25) | 0.1 |
| Mutant | 10.9 (5) | 0 | 100 (5) | |
| Exon 11 | ||||
| Wild type | 54.3 (25) | 48 (12) | 52 (13) | 0.04 |
| Mutant | 45.7 (21) | 19 (4) | 81 (17) | |
| Exon 13 | ||||
| Wild type | 84.8 (39) | 28.2 (11) | 71.8 (28) | 0.04 |
| Mutant | 15.2 (7) | 71.4 (5) | 28.6 (2) | |
| Exon 17 | ||||
| Wild type | 80.4 (37) | 37.8 (14) | 62.2 (23) | 0.32 |
| Mutant | 19.6 (9) | 22.2 (2) | 77.8 (7) | |
| PDGFRA gene | ||||
| Overall | ||||
| Wild type | 76.1 (35) | 34.3 (12) | 65.7 (23) | 0.58 |
| Mutant | 23.9 (11) | 36.4 (4) | 63.6 (7) | |
| Exon 12 | ||||
| Wild type | 84.8 (39) | 33.3 (13) | 66.7 (26) | 0.46 |
| Mutant | 15.2 (7) | 42.9 (3) | 57.1 (4) | |
| Exon 18 | ||||
| Wild type | 82.6 (38) | 36.8 (14) | 63.2 (24) | 0.42 |
| Mutant | 17.4 (8) | 25 (2) | 75 (6) | |