Table 4.
Prediction of human clearance of total antibody by two-species allometric scaling.
| Drugs | Coefficient | Exponent | Predicted | Observed | Ratio * |
|---|---|---|---|---|---|
| DNIB0600A | |||||
| Mouse, monkey | 12.1 | 1.08 | 1190 | 854 | 1.39 |
| Mouse, rat | 21.8 | 1.23 | 3981 | 854 | 4.66 |
| Rat, monkey | 14.5 | 0.93 | 753 | 854 | 0.88 |
| DMOT4039A | |||||
| Mouse, monkey | 21.3 | 1.21 | 3640 | 1400 | 2.60 |
| Polatuzumab vedotin | |||||
| Mouse, monkey | 6.6 | 1.04 | 543 | 1015 | 0.53 |
| Mouse, rat | 28.8 | 1.42 | 12,007 | 1015 | 11.83 |
| Rat, monkey | 10.3 | 0.68 | 185 | 1015 | 0.18 |
| Pinatuzumab vedotin | |||||
| Mouse, monkey | 8.46 | 1.08 | 832 | 966 | 0.86 |
| ADC1 | |||||
| Mouse, monkey | 9.38 | 1.09 | 962 | 756 | 1.27 |
| Brentuximab vedotin | |||||
| Mouse, monkey | 16.6 | 0.89 | 728 | 742 | 0.98 |
| Mouse, rat | 5.1 | 0.59 | 63 | 742 | 0.08 |
| Rat, monkey | 11.6 | 1.18 | 1745 | 742 | 2.35 |
| DSTP3086S | |||||
| Mouse, monkey | 12.4 | 1.09 | 1277 | 574 | 2.22 |
| Mouse, rat | 9.3 | 0.98 | 598 | 574 | 1.04 |
| Rat, monkey | 11.4 | 1.13 | 1386 | 574 | 2.41 |
| T-DM1 | |||||
| Mouse, monkey | 5.3 | 0.89 | 231 | 343 | 0.67 |
| Mouse, rat | 5.4 | 0.87 | 219 | 343 | 0.64 |
| Rat, monkey | 5.8 | 0.92 | 291 | 343 | 0.85 |
| Thiomab | |||||
| Mouse, monkey | 5.6 | 1.03 | 445 | 200 | 2.23 |
| Mouse, rat | 11.6 | 1.21 | 1982 | 200 | 9.91 |
| Rat, monkey | 7 | 0.85 | 259 | 200 | 1.30 |
| Anti-5T4 | |||||
| Mouse, monkey | 9.7 | 0.82 | 316 | 360 | 0.88 |
| Mouse, rat | 10.7 | 0.85 | 388 | 360 | 1.08 |
| Rat, monkey | 10 | 0.80 | 299 | 360 | 0.83 |
* Predicted Ratio = Predicted/Observed.