Table 5.

Predicted human clearance (total antibody) by different exponents from mouse, rat, and monkey.

Species	Predicted				Prediction Ratio
	E 0.75	E 0.80	E 0.85	E 1.0	E 0.75	E 0.80	E 0.85	E 1.0
DNIB0600A (observed human CL = 854 mL/day)
Mouse	82	123	185	630	0.10	0.14	0.22	0.74
Rat	272	361	479	1114	0.32	0.42	0.56	1.30
Monkey	440	511	594	931	0.52	0.60	0.70	1.09
DMOT4039A (observed human CL = 1400 mL/day)
Mouse	86	130	196	665	0.06	0.09	0.14	0.48
Monkey	914	1061	1233	1932	0.65	0.76	0.88	1.38
DSTP3086S (observed human CL = 574 mL/day)
Mouse	90	135	204	693	0.16	0.24	0.35	1.21
Rat	163	215	286	665	0.28	0.38	0.50	1.16
Monkey	444	515	598	938	0.77	0.90	1.04	1.63
TDM1 (observed human CL = 343 mL/day)
Mouse	73	109	165	560	0.21	0.32	0.48	1.63
Rat	111	147	195	455	0.32	0.43	0.57	1.33
Monkey	152	177	205	322	0.44	0.52	0.60	0.94
Polatuzumab vedotin (observed human CL = 1015 mL/day)
Mouse	46	70	105	356	0.05	0.07	0.10	0.35
Rat	185	245	325	756	0.18	0.24	0.32	0.74
Monkey	199	231	268	420	0.20	0.23	0.26	0.41
Pinatuzumab vedotin (observed human CL = 966 mL/day)
Mouse	56	83	126	427	0.06	0.09	0.13	0.44
Monkey	311	361	420	658	0.32	0.37	0.43	0.68
ADC1 (observed human CL = 756 mL/day)
Mouse	60	90	136	462	0.08	0.12	0.18	0.61
Monkey	348	404	469	735	0.46	0.53	0.62	0.97
Brentuximab vedotin (observed human CL = 742 mL/day)
Mouse	55	82	123	420	0.07	0.11	0.17	0.57
Rat	154	204	271	630	0.21	0.28	0.36	0.85
Monkey	483	561	652	1022	0.65	0.76	0.88	1.38
Thiomab (observed human CL = 200 mL/day)
Mouse	44	66	99	338	0.22	0.33	0.50	1.69
Rat	147	195	259	602	0.74	0.98	1.29	3.01
Monkey	193	224	260	407	0.96	1.12	1.30	2.04
Anti-5T4 (observed human CL = 360 mL/day)
Mouse	177	266	400	1361	0.49	0.74	1.11	3.78
Rat	226	299	397	924	0.63	0.83	1.10	2.57
Monkey	256	297	345	541	0.71	0.83	0.96	1.50