Fig. 5.

Effects of T4 on histopathology post-TBI. a Brain sections stained with cresyl violet were shown on the left. Lesion volume was calculated from the sections (n = 3 per group). b Brain water content of traumatized hemisphere increased 1 day post-TBI, whereas T4 alleviates edema (n = 3 per group). c BBB integrity was reflected by detecting the extravasation of EB dye (n = 3 per group). Brain samples from four groups were shown (*p < 0.05, **p < 0.01, and ***p < 0.001 vs. sham + saline; ^#p < 0.05 and ^##p < 0.01 vs. TBI + saline; ns: not significant). Error bars represent standard deviation (SD)