Table 2.

Comparison of changes in skin properties in the full analysis set population.

Variable	Observed values		Changes from baseline
	CTP (n = 36)	CG (n = 38)	CTP (n = 36)	Pa	CG (n = 38)	Pa	Pb	Pc	Pd	Pe
Transepidermal water loss (g/m2/h)
Baseline	6.08 ± 2.1	5.64 ± 1.4
At 6 weeks	4.43 ± 1.6	4.25 ± 1.1	−1.65 ± 1.9	<0.001	−1.39 ± 1.9	<0.001	0.577	0.675	0.411	0.445
At 12 weeks	5.14 ± 1.5	5.31 ± 1.5	−0.94 ± 1.8	0.004	−0.33 ± 1.9	0.297	0.168	0.024	0.032	0.031
Skin hydration (A.U.)
Baseline	192.5 ± 21.4	199.7 ± 21.9
At 6 weeks	199.2 ± 19.6	200.1 ± 24.0	6.73 ± 22.0	0.076	0.45 ± 21.9	0.900	0.223	0.243	0.204	0.214
At 12 weeks	209.0 ± 18.7	212.1 ± 16.0	16.50 ± 21.7	<0.001	12.44 ± 21.7	<0.001	0.423	0.325	0.335	0.278
Skin elasticity (mm)
Baseline	0.40 ± 0.11	0.42 ± 0.10
At 6 weeks	0.35 ± 0.10	0.36 ± 0.10	−0.04 ± 0.1	0.050	−0.06 ± 0.1	0.002	0.574	0.514	0.557	0.642
At 12 weeks	0.33 ± 0.10	0.36 ± 0.09	−0.07 ± 0.1	<0.001	−0.05 ± 0.1	0.002	0.480	0.471	0.546	0.603
Lt. crow's–feet visual score
Baseline	2.25 ± 0.73	2.47 ± 0.98
At 6 weeks	1.94 ± 0.63	1.97 ± 0.88	−0.31 ± 0.6	0.003	−0.50 ± 0.6	<0.001	0.145	0.207	0.148	0.208
At 12 weeks	1.61 ± 0.60	1.71 ± 0.73	−0.64 ± 0.6	<0.001	−0.76± 0.5	<0.001	0.349	0.307	0.303	0.312
Rt. crow's-feet visual score
Baseline	2.11 ± 0.78	2.24 ± 0.94
At 6 weeks	1.61 ± 0.64	1.82 ± 0.83	−0.50 ± 0.6	<0.001	−0.42 ± 0.5	<0.001	0.524	0.417	0.512	0.431
At 12 weeks	1.44 ± 0.56	1.47 ± 0.65	−0.67 ± 0.6	<0.001	−0.76 ± 0.6	<0.001	0.514	0.497	0.537	0.564
Lt. wrinkles by vision meter
Baseline	28.0 ± 6.2	25.8 ± 6.0
At 6 weeks	31.4 ± 6.9	29.3 ± 5.4	3.33 ± 9.2	0.037	3.44 ± 8.3	0.011	0.960	0.797	0.985	0.897
At 12 weeks	29.8 ± 4.8	30.2 ± 6.1	1.82 ± 7.1	0.131	4.41 ± 7.9	0.002	0.141	0.181	0.241	0.286
Rt. wrinkles by vision meter
Baseline	27.2 ± 6.0	27.9 ± 6.8
At 6 weeks	29.3 ± 5.4	28.4 ± 6.1	2.15 ± 7.9	0.117	0.57 ± 8.0	0.663	0.406	0.390	0.334	0.395
At 12 weeks	29.3 ± 5.0	30.5 ± 7.0	2.08 ± 7.4	0.100	2.66 ± 8.6	0.065	0.758	0.894	0.976	0.942

Values are presented as mean ± SD.

^aPaired t-test.

^bTwo-sample t-test.

^cRepeated measures ANCOVA (adjusted for temperature and humidity).

^dANCOVA (adjusted for ultraviolet A).

^eANCOVA (adjusted for temperature, high temperature, and ultraviolet A).