. 2021 Jan 26;5(2):570–583. doi: 10.1182/bloodadvances.2020002948

Table 4.

Summary of the estimated effect sizes in different HRQOL domains following HSCT

Author, y	Domain	Effect size, d	95% confidence interval
Sickle cell disease
PedsQL
Bhatia et al,⁵⁵ 2015	Physical	0.97	(0.22-1.71)^*
	Social	0.77	(0.04-1.48)^*
	Emotional	1.02	(0.28-1.76)^*
	Psychosocial	1.01	(0.27-1.75)^*
	Overall	1.10	(0.34-1.84)^*
Thalassemia
PedsQL
Caocci et al,⁴⁴ 2011	Physical	0.86	(0.31-1.4)^*
	Social	1.06	(0.5-1.62)^*
	Emotional	0.27	(-0.25 to 0.8)
	Psychosocial	1.25	(0.67-1.82)^*
	Overall	2.05	(1.39-2.69)^*
Cheuk et al,⁴⁷ 2008	Physical	0.41	(-0.24 to 1.05)
	Social	0.16	(-0.49 to 0.8)
	Emotional	0.33	(-0.32 to 0.97)
	Psychosocial	0.17	(-0.48 to 0.81)
	School	−0.08	(-0.72 to 0.56)
	Overall	0.21	(0.22-0.18)^*
Patel et al,⁵¹ 2018	Physical	0.78	(0.32-1.23)^*
	Social	0.26	(-0.18 to 0.7)
	Emotional	0.72	(0.26-1.17)^*
	Psychosocial	0.80	(0.34-1.26)^*
	School	0.86	(0.4-1.31)^*
	Overall	0.69	(0.24-1.14)^*
Uygun et al,⁵² 2012	Physical	1.07	(0.56-1.57)^*
	Social	0.53	(0.05-1.01)^*
	Emotional	0.78	(0.29-1.26)^*
	School	0.63	(0.15-1.11)^*
	Psychosocial	0.55	(0.07-1.02)^*
	Overall	0.71	(0.23-1.19)^*
SF-36
Caocci et al,⁴⁶ 2016 (Thalassemia control)	Physical Component Score	0.82	(0.48-1.16)^*
Caocci et al,⁴⁶ 2016 (Thalassemia control)	Mental Component Score	0.57	(0.23-0.9)^*
Caocci et al,⁴⁶ 2016 (Sibling control)	Physical Component Score	−0.27	(-0.6 to 0.06)
Caocci et al,⁴⁶ 2016 (Sibling control)	Mental Component Score	0.40	(0.06-0.73)^*
Javanbakht et al,⁴⁸ 2015	Physical	0.50	(0.16-0.84)^*
	Role Physical	0.52	(0.18-0.86)^*
	Bodily Pain	−0.02	(-0.35 to 0.32)
	General Health	0.19	(-0.14 to 0.53)
	Vitality	0.22	(-0.11 to 0.56)
	Social Functioning	0.33	(-0.01 to 0.66)
	Role Emotional	0.57	(0.23-0.91)^*
	Mental Health	0.26	(-0.08 to 0.6)
La Nasa et al,⁵⁰ 2013 (Transfusion control)	Physical	0.17	(-0.09 to 0.43)
	Role Physical	0.88	(0.61-1.15)^*
	Bodily Pain	0.82	(0.56-1.09)^*
	General Health	0.20	(-0.06 to 0.46)
	Vitality	0.28	(0.02-0.54)^*
	Social Functioning	−0.04	(-0.3 to 0.21)
	Role Emotional	0.63	(0.37-0.9)^*
	Mental Health	0.18	(-0.08 to 0.43)
La Nasa et al,⁵⁰ 2013 (Matched general population control)	Physical	0.05	(-0.22 to 0.31)
	Role Physical	0.29	(0.02-0.55)^*
	Bodily Pain	0.23	(-0.04 to 0.49)
	General Health	−0.11	(-0.37 to 0.16)
	Vitality	0.13	(-0.14 to 0.4)
	Social Functioning	0.20	(-0.07 to 0.47)
	Role Emotional	0.39	(0.12-0.65)^*
	Mental health	0.41	(0.14-0.68)^*
WHOQoL-BREF
Cheuk et al,⁴⁷ 2008	Physical	0.79	(0.21-1.35)^*
	Global	0.26	(-0.3 to 0.82)
	Cultural adjusted	0.22	(-0.34 to 0.78)
	Social Relationships	0.36	(-0.2 to 0.92)
	Environment	0.06	(-0.5 to 0.61)
Uygun et al,⁵² 2012	Physical	0.91	(-0.01 to 1.81)
	Psychological	0.22	(-0.65 to 1.09)
	Social Relationships	1.24	(0.27-2.17)^*
	Environment	0.34	(-0.53 to 1.21)

Indicates an effect size with statistically significant improvement in a quality-of-life domain following hematopoietic stem cell transplant (<0.05).