Table 3.

Relevant adverse events presented by patients and by highest intensity

	Grade 1-2	Grade 3	Grade 4	Grade 5
Hematologic toxicity
Neutropenia	5 (6)	15 (19)	55 (71)	0 (0)
Anemia	27 (34)	26 (33)	3 (3)	0 (0)
Thrombocytopenia	12 (15)	12 (15)	24 (31)	0 (0)
Febrile neutropenia	0 (0)	9 (11)	4 (5)	0 (0)
Infection
Sepsis	1 (1)	5 (6)	6 (8)	4 (5)*
Pneumonia	1 (1)	5 (5)	1 (1)	0 (0)
Upper respiratory tract infection	12 (15)	0 (0)	0 (0)	0 (0)
Digestive tract infection	0 (0)	2 (3)	0 (0)	0 (0)
Urinary tract infection	4 (5)	2 (3)	0 (0)	0 (0)
Other	9 (12)	2 (3)	1 (1)	0 (0)
Nonhematologic adverse events
Fatigue	15 (19)	4 (5)	0 (0)	0 (0)
Nausea/vomiting	18 (23)	4 (5)	0 (0)	0 (0)
Peripheral neuropathy	12 (15)	2 (3)	0 (0)	0 (0)
Rash	7 (9)	2 (3)	0 (0)	0 (0)
Thrombosis	7 (9)	1 (1)	0 (0)	0 (0)

Data are n (%). Hematologic adverse events, infection, and events occurring in more than 15% of the 78 patients.

*Patient died of septic shock, related to treatment, and had progressive lymphoma.