Table 2.
Imaging, pathology, and laboratory characteristics by first-line management (N = 123)
| Characteristic | Overall | Active surveillance (n = 58) | Surgical resection (n = 51) | Systemic treatment (n = 14) | P |
|---|---|---|---|---|---|
| Both lungs | 10 (8) | 8 (14) | 0 (0) | 2 (14) | .007 |
| No. of lesions | .005 | ||||
| 1 | 94 (76) | 39 (67) | 46 (90) | 9 (64) | |
| ≥2 | 29 (24) | 19 (33) | 5 (9.8) | 5 (36) | |
| Median size (IQR), cm | 2.50 (1.50-3.50) | 2.35 (1.50-2.80) | 2.60 (1.60-3.45) | 5.50 (3.48-7.45) | <.001 |
| Size category, cm* | .3 | ||||
| ≤1 | 9 (7.3) | 5 (8.6) | 3 (5.9) | 1 (7.1) | |
| >1 to ≤2 | 35 (28) | 20 (34) | 14 (27) | 1 (7.1) | |
| >2 | 79 (64) | 33 (57) | 34 (67) | 12 (86) | |
| Pleural involvement | 23 (19) | 13 (22) | 9 (18) | 1 (7.1) | .5 |
| Pleural effusion | 14 (11) | 5 (8.6) | 6 (12) | 3 (21) | .4 |
| Nodal disease in chest | 6 (4.9) | 3 (5.2) | 3 (5.9) | 0 (0) | >.9 |
| Ki67 (percent positive)† | 5 (5-10) | 5 (5-10) | 5 (5-10) | 8 (5-12) | .7 |
| Anemia (Hb <11 g/dL) | 11 (8.9) | 8 (14) | 3 (5.9) | 0 (0) | .2 |
| Neutropenia (<1.5 × 103/µL) | 2 (1.6) | 1 (1.7) | 0 (0) | 1 (7.1) | .2 |
| Thrombocytopenia (<150 × 103/µL) | 7 (5.7) | 4 (6.9) | 1 (1.9) | 2 (14) | .15 |
| LDH >ULN | 9 (7.3) | 6 (10) | 2 (3.9) | 1 (7.1) | .8 |
Data presented as no. (%) or median (IQR). Boldface P values indicate statistical significance (P < .05).
Hb, hemoglobin; LDH, lactate dehydrogenase; ULN, upper limit of normal.
*
Largest tumor.
†
There were 74 patients with available data for evaluation.