Table 5.
OS and EFS by the levels of Native American ancestry in the genotyped subcohort of the DFCI 05-001 trial
| Native American ancestry | No. of events/total | Unadjusted model | Adjusted model* | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| OS | |||||
| Below median (<0.006) | 5/236 | 1.00 | 1.00 | ||
| Above median (≥0.006) | 15/213 | 3.62 (1.32-9.96) | .01 | 4.00 (1.45-11.02) | .007 |
| EFS | |||||
| Below median (<0.006) | 17/236 | 1.00 | 1.00 | ||
| Above median (≥0.006) | 28/213 | 1.96 (1.07-3.59) | .03 | 2.07 (1.13-3.79) | .02 |
The numbers in the parentheses in the left column indicate the cutoff points of the proportion of Native American ancestry an individual carries that ranges between 0 and 1.
*
Multivariable Cox models were adjusted for age, sex, and final risk group.