Table 2.
Lowest fibrinogen level by CRS grade
| Grade 1-2 (n = 51) | Grade 3 (n = 27) | Grade 4 (n = 30) | Patients with CRS (n = 108) | No CRS (n = 29) | |
|---|---|---|---|---|---|
| Lowest fibrinogen, g/L | |||||
| Patients, n | 44 | 26 | 30 | 100 | 29 |
| Mean (SD) | 3.7 (1.2) | 3.2 (1.6) | 1.8 (1.2) | 3.0 (1.6) | 2.7 (0.8) |
| Median | 3.5 | 3.1 | 1.3 | 3.1 | 2.7 |
| Min-max | 1.4-6.3 | 0.9-6.8 | 0.4-5.5 | 0.4-6.8 | 0.8-3.8 |
| Lowest fibrinogen category, n (%), g/L | |||||
| <1 | 0 | 1 (3.7) | 8 (26.7) | 9 (8.3) | 2 (6.9) |
| ≥1 to <1.5 | 1 (2.0) | 4 (14.8) | 8 (26.7) | 13 (12.0) | 0 |
| ≥1.5 | 43 (84.3) | 21 (77.8) | 14 (46.7) | 78 (72.2) | 27 (93.1) |
Median reference range for fibrinogen across 2 age groups (6-10 y and 11-17 y) and 2 reagents = 2.48-2.78 g/L.17For patients with CRS, nadir fibrinogen is measured during CRS; for patients without CRS, nadir fibrinogen is measured within 1 mo postinfusion.
SD, standard deviation.