Table 2.
Comparison of clinical, biological and radiological characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) who did and did not receive antibiotic therapy.
| Antibiotic therapy (n = 174) | No antibiotic therapy (n = 48) | P-value | |
|---|---|---|---|
| Time between symptom onset and hospital admission (days), median (IQR) | 6.0 (3.0–9.0) | 5.0 (2.0–9.0) | 0.19 |
| Clinical signs before admission | |||
| Fevera, n (%) | 143 (82) | 26 (54) | <0.001 |
| Cough, n (%) | 120 (69) | 26 (54) | 0.06 |
| Dyspnoea, n (%) | 118 (68) | 19 (40) | <0.001 |
| Flu-likesyndrome, n (%) | 59 (34) | 23 (48) | 0.08 |
| Digestive disorders, n (%) | 53 (30) | 13 (27) | 0.65 |
| Confusion, n (%) | 32 (18) | 5 (10) | 0.19 |
| Anosmia, n (%) | 10 (6) | 3 (6) | 0.90 |
| Dysgeusia, n (%) | 17 (10) | 0 (0) | 0.02 |
| NEWS at D0, median (IQR) | 6.0 (4.0–8.0) | 2.0 (1.0–5.0) | <0.001 |
| Biological features at admission | |||
| Neutrophils, g/L, median (IQR) | 4.8 (3.5–7.3) | 4.2 (2.8–6.0) | 0.06 |
| Lymphocytes, g/L, median (IQR) | 0.9 (0.6–1.2) | 1.1 (0.8–1.8) | 0.02 |
| Fibrinogen, g/L, median (IQR) | 6.0 (5.3–6.0) | 5.5 (4.8–6.3) | 0.04 |
| C-reactive protein, mg/L, median (IQR) | 94.0 (52.5–135.0) | 29.1 (9.2–73.0) | <0.001 |
| Thoracic CT scanb | 0.01 | ||
| Non-evocative of COVID-19, n (%) | 11 (8) | 6 (24) | |
| Minimal, n (%) | 13 (9) | 6 (24) | |
| Moderate, n (%) | 45 (32) | 8 (32) | |
| Extensive, n (%) | 45 (32) | 3 (12) | |
| Severe, n (%) | 21 (15) | 1 (4) | |
| Critical, n (%) | 4 (3) | 1 (4) |
IQR, interquartile range; NEWS2, National Early Warning Score 2; D0, Day 0 (i.e. day of hospital admission); CT, computer tomography.
a
Defined as temperature >38 °C.
b
Degree of lesions on CT scan: non-evocative (0%), minimal (1–15%), moderate (15–25%), extensive (25–50%), severe (50–75%) and critical (>75%).